Projects

The Bill and Melinda Gates Foundation (BMGF) has established and funded a Systems Biology/Systems Immunology Consortium to discover and validate molecular, immunological, and clinical signatures of vaccine efficacy for infectious diseases.

The Global Health Vaccine Accelerator Platform (GH-VAP) program is designed to benefit Bill & Melinda Gates Foundation (BMGF) Grantees and Partners by linking researchers with best-in-class research services to accelerate vaccine discovery and translation. Based on the successful model of CAVD (Collaboration for AIDS Vaccine Discovery), GH-VAP leverages existing infrastructure to provide broader access to select research platforms for BMGF grantees across disease areas. Standard conditions and agreements for access to data and a secure GH-VAP web portal provide uniform mechanisms by which grantees can request collaborative research support to accelerate their BMGF-funded vaccine discovery projects.

Stanford CHSI has tailored approaches based on study design and scientific priorities developed in collaboration with our GH-VAP partners as well on a pilot projects that are in strategic alignment with the goals of the foundation.

Below are previously funded or current GH-VAP projects and pilots.

  • SI-ID-3 Immunophenotyping of the PROVIDE cohort during child development and association with vaccine response and nutritional status
    Mark Davis, PhD, Stanford University
    Bill Petri, MD, PhD, University of Virginia School of Medicine, VA
    2015-2017
  • SI-ID-7 Single cell analysis of TCR repertoire & cellular phenotype of Dengue specific CD4+ T cells
    Holden Maecker, PhD, Stanford University
    Alex Sette, PhD, La Jolla Institute for Immunology, La Jolla, CA
    2015
  • SI-ID-12 Study of TB specific T cells 
    Mark Davis, PhD, Stanford University
    Alex Sette, La Jolla Institute for Immunology, La Jolla, CA
    2015-2016
  • SI-ID-13 Single cell characterization of TB-specific gd T cells
    Yueh-Hsiu Chien, PhD, Stanford University
    Dan Hoft, MD, PhD, Saint Louis University, MO
    2016-2019
  • SI-ID-14 The role of commensal bacteria in the development of broadly neutralizing antibodies in HIV infection
    Stephen Quake, PhD, Stanford University
    Penny Moore, PhD, University of the Witwatersrand, Johannesburg, South Africa
    2016-2018
  • GH-VAP-SI-ID-16 The relationship of MAIT cell TCR usage, ligand recognition and disease phenotype
    Holden Maecker, PhD, Stanford University
    David Lewinsohn, Oregon Health & Science University, Portland, USA
    2016-2018
  • SI-ID-18 Systems immunology analysis of T cell response in 3BNC117 treated patients 
    Mark Davis, PhD, Stanford University
    Michel Nussenzweig, Rockefeller University, NYC, USA
    2016-2018
  • SI-ID-19 CyTOF Intercenter Study
    Mark Davis, PhD, Stanford University
    2015
  • SI—MHC II & MHC E restricted CD8+ T
    Holden Maecker, PhD, Stanford University
    Louis Picker, MD, OHSU School of Medicine
    2014-2017
  • SI-ID-20 Transcriptional profiling of macrophages from TB Resisters
    Purvesh Khatri, PhD, Stanford University
    Thomas Hawn, MD, PhD, University of Washington, WA
    2016
  • SI-ID-21 Analysis of the immune state of latent M.tb infection and its progression to active disease 
    Mark Davis, PhD, Stanford University
    Yueh-Hsiu Chien, PhD, Stanford University
    Purvesh Khatri, PhD, Stanford University
    Thomas Scriba, PhD, South African Tuberculosis Vaccine Initiative, Cape Town, South Africa
    2016-2019
  • SI-ID-CC-9 Cellular Immunity to Vaccination Against Typhoid Fever (VAST)
    Holden Maecker, PhD, Stanford University 
    Catherine Blish, MD, PhD, Stanford University
    Nima Aghaeepour, PhD, Stanford University
    Andrew Pollard, Oxford Vaccine Group, Oxford, UK
    2017-2019
  • SI-ID-CC-12 Investigating the Role of Typhoid Toxin in the Pathogenesis of Typhoid Fever – Analysis of early and acute disease cytokine responses (TYGER Study)
    Holden Maecker, PhD, Stanford University
    Andrew Pollard, Oxford Vaccine Group, Oxford, UK
    2017-2018
  • SI-ID-25 Statistical analysis of the antibody repertoires induced in the Dengue human infection model
    Scott Boyd, MD, PhD, Stanford University
    Katherine Jackson, Garvan Institute, Sydney, Australia 
    Anna Durbin, Johns Hopkins University, Baltimore, USA
    Sean Diehl, University of Vermont, Burlington, USA
    2017-2018
  • SI-ID-26 Genomic and Immunological Indicators of Preterm Delivery
    Purvesh Khatri, PhD, Stanford University
    2017-2019
  • SI-ID-27 T-cell responses to mycobacterial lipids in NHP models – CD1 Tetramers for Rhesus and Cynomolgus Macaque
    Sub-award John Altman, PhD Emory University
    Chetan Seshadri, MD, University of Washington, Seattle, USA,
    2018-2019
    *Stanford’s role in this project was administrative only via the subcontract to Dr. Altman by Stanford’s Center for Human Systems Immunology (GH-VAP partner).
  • SI-ID-28 Development of a prototype ‘paper-based’ point-of-care diagnostic test for active Tuberculosis
    Rhiju Das, PhD, Stanford University
    Purvesh Khatri, PhD, Stanford University
    2017-2020
  • SI-ID-29 RNA-Seq analysis of samples from VRC TB vaccine studies
    Purvesh Khatri, PhD, Stanford University
    Robert Seder, MD, National Institute of Allergy and Infectious Diseases
    2019-
  • SI-ID-30 Novel Mycobacterial MR1 tetramers
    John Altman, Emory University
    David Lewinsohn, Oregon Health & Science University
    2018-2019
    *Stanford’s role in this project was administrative only via the subcontract to Dr. Altman by Stanford’s Center for Human Systems Immunology (GH-VAP partner).
  • SI-ID-32 Generation of an Immune Atlas of Tuberculosis Granulomas in Human and NHP
    Mike Angelo, MD, PhD, Stanford University
    Sarah Fortune, MD, Ragon Institute of MGH, Harvard, and MIT, Cambridge, USA
    2018-2021
  • SI-ID-33 How nasal carriage of pneumococcus immunizes the human lung
    Holden Maecker, PhD, Stanford University
    Simon Jochems, PhD, and Daniela Ferreira, PhD, Liverpool School of Topical Medicine, UK
    2019-pending
  • SI-ID-34 Generation of an Immune Atlas of Tuberculosis Granulomas in Human and NHP
    Mark Davis, PhD, Stanford University
    Chetan Seshadri, MD, University of Washington, WA
    2018-2020
  • SI-ID-35 Natural killer cells and KLF2 in the pathogenesis of Mycobacterium Tuberculosis
    Catherine Blish, MD, PhD, Stanford University
    Purvesh Khatri, PhD, Stanford University
    Jason Andrews, MD, Stanford University
    Julio Croda, MD, PhD, FIOTEC, Brazil
    2018-2021
  • SI-ID-36 Transcriptomic analysis of RhCMV vector vaccines in NHP SIV and TB Challenge Studies
    Purvesh Khatri, PhD, Stanford University
    Michael Gale, PhD, University of Washington and Louis Picker, MD, OHSU
    2019-
  • SI-ID-37 Human Cellular Models of Neonatal Brain Hypoxia
    Anca Pasca, MD, Stanford University
    2019-2020
  • SI—Mal068 Stanford CyTOF Study: Assessing immune responses by Cytometry by Time-of-Flight (CyTOF) in RTS,S/Ad35.CS Prime Boost Vaccine clinical trial
    Yueh-Hsiu Chien, PhD, Stanford University
    Holden Maecker, PhD, Stanford University
    Ulli Wille-Reece, PATH and Erik Jongert, GSK
    2016-2017
  • SI-ID-40 TB Immune Correlates Program SDMC / EpiTOF
    Purvesh Khatri, PhD, Stanford University
    PJ Utz, MD, Stanford University
    Holden Maecker, PhD, Stanford University
    Jan-Michael Frahm, PhD, University of North Carolina at Chapel Hill
  • SI-ID-40 Walker Specificities in HIV-1 infected, HLA-B57+ individuals
    Mark Davis, PhD, Stanford University
    Lotta von Boehmer, MD, PhD
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